Harris Lab

ME Harris publications on PubMed: CLICK HERE

  • Harris ME, Moore DR and Hajduk SL. (1990). Addition of uridines to edited RNAs in trypanosome mitochondria occurs independently of transcription. J. Biol. Chem. 265, 11368-11376. 1990 Harris et al JBC
  • Harris ME, Böhni R, Schneiderman MH, Ramamurthy L, Schümperli D and Marzluff WF. (1991). Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting two post-transcriptional steps. Molec. Cell. Biol. 5, 2416-2424. 1991 Harris et al MCB
  • Adler B, Harris ME, Bertrand KI and Hajduk SL. (1991). Modification of Trypanosoma brucei mitochondrial rRNA by post-transcriptional 3′ polyuridine tail formation. Molec. Cell. Biol. 12, 5878-5884. 1991 Adler et al MCB
  • Harris ME, Decker C, Sollner-Webb B and Hajduk SL. (1992). Specific cleavage of pre-edited RNAs in extracts from trypanosome mitochondria. Molec. Cell. Biol. 6, 2591-2598. 1992 Harris et al MCB
  • Harris ME and Hajduk SL. (1992). In vitro formation of gRNA/mRNA chimeras from synthetic substrate RNAs. Cell. 68, 1091-1099. 1992 Harris et al Cell
  • Gabb HA, Harris ME, Pandey NB, Marzluff WF and Harvey SC. (1992). Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence. J. Biomolec. Struc. and Dynam. 9, 1119-1130.
  • Michelotti EF, Harris ME, Adler BK, Torri A and Hajduk SL. (1992). Trypanosoma brucei mitochondrial ribosomal RNA synthesis, processing and developmentally regulated expression. Molec. Biochem. Parasitol. 54, 31-42. 1992 Michelotti et al Molec Biochem Parasitol
  • Pollard VW, Harris ME and Hajduk SL. (1992). Native RNA editing complexes from trypanosome mitochondria. EMBO J. 7, 4429-4438. 1992 Pollard et al EMBO J
  • Hajduk SL, Adler B, Bertrand K, Hager K, Harris ME, Moore D, Priest J and Wood Z. (1992). Molecular biology of african trypanosomes: Development of new strategies to combat an old disease. Am. J. Med. Sci. 303, 258-270.
  • Hajduk SL, Harris ME and Pollard VW. (1993). RNA editing in trypanosome mitochondria. FASEB J. 7, 54-63. 1992 Hajduk et al FASEB J
  • Harris ME, Nolan JM, Malhotra A, Brown JW, Harvey SC and Pace NR. (1994). Use of photoaffinity crosslinking and molecular modeling to analyze the global architecture of ribonuclease P RNA. EMBO J. 13, 3953-3960. 1994 Harris et al EMBO J
  • Frank D, Harris ME and Pace NR. (1994). Rational design of self-cleaving pre-tRNA ribonuclease P RNA conjugates. Biochemistry. 33, 10800-10808. 1994 Frank et al Biochem
  • Harris ME and Pace NR. (1995). Identification of phosphates involved in catalysis by the ribozyme RNase P RNA. RNA. 1, 210-218. 1995 Harris et al RNA
  • Piller KJ, Decker CJ, Rusche L, Harris ME, Hajduk SL and Sollner-Webb B. (1995). Editing domains of Trypanosoma brucei mitochondrial RNAs identified by secondary structure. Molec. Cell. Biol. 15, 2916-2924. 1995 Piller et al MCB
  • Harris ME and Pace NR. (1996). Analysis of the tertiary structure of bacterial RNase P RNA. Molec. Biol. Reports. 22,115-123. 1996 Harris et al Mol Biol Reports
  • Harris ME, Frank D and Pace NR. (1997). “Structure and catalytic function of bacterial ribonuclease P RNA” in RNA Structure and Function. R.W. Simons and M. Grunberg-Manago eds., Cold Spring Harbor Laboratory Press. 1997.
  • Harris ME, Kavansev A, Chen J-L and Pace NR (1997). Analysis of the tertiary structure of the ribonuclease P ribozyme-substrate complex by site-specific photoaffinity crosslinking . RNA. 3, 561-576.
  • Chen J-L, Nolan JM, Harris ME and Pace NR. (1998). Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillis subtilis RNase P RNAs. EMBO J. 17, 1515-1525. 1998 Chen et al EMBO J
  • Christian EL, McPheeters DS and Harris ME. (1998). Identification of individual nucleotides in the bacterial ribonuclease P ribozyme adjacent to the pre-tRNA cleavage site by short-range photocrosslinking. Biochemistry. 37, 17618-17628. 1998 Christian et al Biochem
  • Siew D, Zahler N, Cassano A, Strobel S and Harris ME. (1999). Identification of individual adenosine chemical groups involved in substrate recognition by the ribonuclase P ribozyme. Biochemistry. 38, 1873-1883.
  • Christian EL and Harris ME. (1999) The track of the pre-tRNA 5′ leader sequence in the ribonuclease P ribozyme-substrate complex. Biochemistry. 38, 12629-12638. 1999 Christian et al Biochem
  • Harris ME and Christian EL. (1999). Use of circularly permutation and end-modification to position photoaffinity probes for analysis of RNA structure. Methods. 18, 51-59. 1999 Harris et al Methods
  • Christian EL, Kaye NM and Harris ME. (2000). Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme. RNA. 6, 511-519. 2000 Christian et al RNA
  • Campbell FE, Cassano AG, Anderson V and Harris ME. (2002). Pre-steady state and stopped flow fluorescence analysis of E. coli RNase III: Insights into mechanism and conformational changes associated with binding and catalysis. J. Molec. Biol. 317, 21-40. 2002 Campbell et al J Molec Biol
  • Kaye NM, Christian EL and Harris ME. (2002). NAIM and site-specific functional group modification analysis of the RNase P ribozyme: Magnesium dependent structure in the P1-P4 multi-helix junction contributes to catalysis. Biochemistry. 41, 4533-4545. 2002 Kaye et al Biochem
  • Christian EL, Kaye NM and Harris ME. (2002). Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. EMBO J. 21, 2253-2262. 2002 Christian et al EMBO J
  • Cassano AG, Anderson VE and Harris ME. (2002). Evidence for direct attack by hydroxide in phosphodiester hydrolysis. J. Am. Chem. Soc. 124(37):10964-5. 2002 Cassano et al JACS
  • Kaye NM, Zahler NH, Christian EL and Harris ME. (2002). Conserved helix structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA. J. Molec Biol. 324(3):429-442. 2002 Kaye et al J Molec Biol
  • Christian EL, Kaye NM, Zahler, NH and Harris ME. (2002). Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P. Methods. 28, 307-322. 2002 Christian et al Methods
  • Zahler NH, Christian EL and Harris ME. (2003). Recognition of the 5′ leader of pre-tRNA substrates by the active site of ribonuclease P. RNA. 9, 734-745. 2003 Zahler et al RNA
  • Harris ME and Christian EL. (2003). Recent insights into the structure and function of the ribonucleoprotein enzyme RNase P. Curr. Op. Struct. Biol. 13, 325-333. 2003 Harris et al Curr Op Struct Biol
  • Zahler, NH and Harris ME. (2004). “Site-Specific Modification of RNA” in Handbook of RNA Biochemistry, Wiley. Hartmann, Binderief, Shon and Westhof, eds.
  • Harris ME and Christian EL. (2004). “Probing RNA Structure by Photoaffinity Crosslinking With 4-Thiourine and 6-Thioguanosine” in Handbook of RNA Biochemistry, Wiley. Hartmann, Binderief, Shon and Westhof, eds.
  • Cassano AG, Anderson VE and Harris ME. (2004). Analysis of solvent nucleophile isotope effects: Evidence for concerted mechanisms and nucleophilic activation by metal ion coordination in non-enzymatic and ribozyme catalyzed phosphodiester hydrolysis. Biochemistry. 43(32):10547-59. 2004 Cassano et al Biochem
  • Cassano AG, Anderson, VE and Harris ME. (2004). Transition states of phopshodiester bond hydrolysis: Information from heavy atom isotope effects. Biopolymers. 73, 110-129. 2004 Cassano et al Biopolymers
  • Zahler NH, Sun L, Christian, EL and Harris ME (2005). The pre-tRNA nucleotide base and 2′-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P. J. Molec. Biol. 345(5):969-85. 2005 Zahler et al J Molec Biol
  • Anderson VE, Harris ME and Cassano AG. (2006) “Nucleophile Isotope Effects” in Isotope Effects in Chemistry and Biology. CRC Press. Kohen A, Limbach H-H (eds)
  • Guo X, Campbell FE, Christian EL, Anderson VE and Harris ME. (2006) RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme. J. Molec. Biol. 360(1):190-203. 2006 Guo et al J Molec Biol
  • Christian EL, Johnson K, Perrera N and Harris ME. (2006). Evidence for a role for the P4 metal binding site in enhancing catalytic metal ion affinity by substrate positioning. RNA. 12(8):1463-7. 2006 Christian et al RNA
  • Sun L, Campbell FE and Harris ME. (2006). Substrate specific effects of C5 protein lead to uniformity in binding and catalysis by RNase P. EMBO J. 25(17):3998-4007. 2006 Sun et al EMBO J
  • Anderson VE, Ruszczysky M and Harris ME. (2006). Nucleophilic activation in enzyme catalysis. Chem. Rev. 106(8):3236-51. 2006 Anderson et al Chem Rev
  • Sun L and Harris ME. (2007).Binding of C5 protein to the P RNA ribozyme increases catalytic rate by influencing active site metal ion affinity. RNA. 34:1-11. 2007 Sun et al RNA
  • Cassano AG, Wang B, Anderson DR, Previs S, Harris ME and Anderson VE. (2007). Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal. Biochem. 367(1):28-39. 2007 Cassano et al Anal Biochem
  • Harris ME and Christian EL. (2008). “Probing RNA Structure by Photoaffinity Crosslinking with 4-Thiouridine and 6-Thioguanosine” in Handbook of RNA Biochemistry, 2nd ed. pp 374-384. Hartmann RK, Bindereif A, Schön A, and Westhof E, eds. Wiley. ISBN: 9783527308262
  • Zahler N and Harris ME. (2008). “Co- and Post-Transcriptional Incorporation of Specific Modifications Including Photoreactive Groups into RNA Molecules” in Handbook of RNA Biochemistry, 2nd ed. pp. 75-85. Hartmann RK, Bindereif A, Schön A, and Westhof E, eds. Wiley. ISBN: 9783527308262
  • Dai Q, Frederiksen JK, Anderson VE, Harris ME and Piccirilli JA. (2008). Efficient synthesis of [2′-18O]uridine and its incorporation into oligonucleotides: A new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J. Org. Chem. 73(1):309-11. 2007 Dai et al J Org Chem
  • Harris ME and Cassano AG. (2008). Experimental analyses of the chemical dynamics of ribozyme catalysis. Curr. Opin. Chem. Biol. 12(6):626-39. 2008 Harris et al Curr Op Chem Biol
  • Christian EL and Harris ME. (2009). “RNA crosslinking methods” in Biophysical, Chemical, and Functional Probes of RNA Structure, Interactions and Folding: Part A Methods in Enzymology Volume 468, pp. 127-146. Herschlag, D. ed. Elsevier. ISBN: 978-0-12-374399-2. 2009 Christian et al Meth Enzymol
  • Harris ME. (2009). “Catalytic Modes of Biological Ribozymes” in Wiley Encyclopedia of Chemical Biology. Begley T. ed. Wiley. ISBN: 978-0-471-75477-0.
  • Harris ME and Christian EL. (2009). “Understanding the role of meal ions in RNA folding and function: Lessons from RNase P, a ribonucleoprotein enzyme” in Non-Protein Coding RNAs. pp183-214. Walter NG, Woodson SA and Batey RT, eds. Springer-Verlag Berlin Heidelberg ISBN 0932-2353
  • Schroeder LA, Gries TJ, Saecker RM, Record MT Jr, Harris ME and DeHaseth PL. (2009). Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J. Molec Biol 385, 339–349. 2009 Schroeder et al J Molec Biol
  • Harris ME and Yandek LE. (2010). “Challenges in substrate recognition by RNase P: Facing up to the biological context” in Protein Reviews Volume 10: Ribonuclease P. pp 135-152. Altman S and Lui F, eds. Springer New York. ISBN 978-1-4419-1141-4
  • Sun L, Campbell FE, Yandek LE and Harris ME. (2010). Binding of the C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus G(1)-C(72) base pair. Handbook of RNA Biochemistry 395(5):1019-37. PMID: 19917291.
  • Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME and Fierke CA. (2010). Protein-precursor tRNA contact leads to sequence-specific recognition of 5′ leaders by bacterial ribonuclease P. J. Mol. Biol. 12;396(1):195-208. 2010 Koutmou et al J Molec Biol
  • Christian EL, Anderson VE, Carey PR and Harris ME. (2010). A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution. Biochemistry. 49(13):2869-79. 2010 Christian et al Biochem
  • Harris ME, Dai Q, Gu H, Kellerman DE, Piccirilli JA and Anderson VE (2010). Kinetic isotope effects for RNA cleavage by 2′-O-transphosphorylation: Nucleophilic activation by specific base. J. Am. Chem. Soc. 132(33):11613-21.
  • Christian EL, Anderson VE, Carey PC and Harris ME (2011). Deconvolution of electrostatic, H-bonding, and inner-sphere coordination interactions and dimethyl phosphate in solution by Raman spectroscopy. J. Inorg. Biochem. 105(4):538-47. 2011 Christian et al J Inorg Biochem
  • Lee TS, Giambaşu G, Harris ME and York DM. (2011). Characterization of the structure and dynamics of the HDV ribozyme at different stages along the reaction path. J. Phys. Chem. 2(20):2538-2543. 2011 Lee et al J Phys Chem Lett
  • Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris ME and Bonomo RA. (2012). Exploring the role of a conserved class a residue in the -loop of KPC-2 β-lactamase: A mechanism for ceftazidime hydrolysis. J. Biol. Chem. 287(38):31783-93. 2012 Levitt et al J Biol Chem
  • Papp-Wallace K, Senkfor B, Gatta J, Chai W, Taracila M, Shanmugasundaram M, Han S, Zaniewski R, Lacey B, Tomaras A, Skalweit M, Harris ME, Rice L, Buynak J and Bonomo RA. (2012). Early insights into affinity of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter spp. PBP1a and PBP3. Antimicrob. Agents Chemother. 56(11):5687-92. 2012 Papp_Walace et al Anti Microb Chemo
  • Wong K-U, Gu H, Zhang S, Piccirilli JA, Harris ME and York D (2012). Characterization of the reaction path and transition states for RNA transphosphorylation from theory and experiment. Angew. Chem. Intl. Ed. 51(3):823.2012 Wong et al Angw Chem Intl Ed
  • Harris ME. (2013). “Identification and Characterization of metal ion coordination interactions with RNA by quantitative analysis of thiophilic metal ion rescue of site-specific phosphorothioate modifications”. in Handbook of RNA Biochemistry, 3rd ed. Hartmann RK, Bindereif A, Schön A, and Westhof E, eds. Wiley-VCH. ISBN: 978-3527327645
  • Harris ME. (2013). “Probing RNA solution structure by photocrosslinking: Incorporation of photoreactive groups at RNA termini and determination of crosslinked sites by primer extension”. in Handbook of RNA Biochemistry, 3rd ed. Hartmann RK, Bindereif A, Schön A, and Westhof E, eds. Wiley-VCH. ISBN: 978-3527327645
  • Radak BK, Harris ME and York DM. (2013). Molecular simulations of RNA 2′-O-transesterification reaction models in solution. J. Phys. Chem. 117(1):94-103. 2013 Radak et al J Phys Chem B
  • Yandek LE, Lin H-C and Harris ME. (2013). Alternative substrate kinetics of Escherichia coli ribonuclease P: Determination of relative rate constants by internal competition. J. Biol. Chem. 288(12):8342-54
  • Corriveau M, Mullins MR, Baus D, Harris ME and Taylor DJ (2013). Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J. Biol. Chem. 288(23):16361-70. 2013 Corriveau et al J Biol Chem
  • Gu H, Zhang S, Wong K-Y, Radak BK, Dissanayake T, Kellerman D, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA and Harris ME. (2013). Experimental and computational analysis of the transition state for ribonuclease A catalyzed RNA 2′-O-transphosphorylaiton. Proc. Natl. Acad. Sci. USA 110(32):13002-13007. 2013 Gu et al PNAS
  • Guenther U-P, Yandek LY, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris ME and Jankowsky E. (2013). Hidden specificity in an apparently non-specific RNA-binding protein. Nature 502(7471):385-8. 2013 Guenther et al Nature
  • Chen H, Giese TJ, Huang M, Wong K-Y, Harris ME and York DM. (2014). Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions. Chem Eur J. 20(44):14336-43. 2013 Chen et al Chem Eur J
  • Lin H-C, Yandek LY, Germeni I and Harris ME. (2014). Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal. Biochem. 467(2): 54-61. 2014 Lin et al Anal Biochem
  • Kellerman DL, York DM, Piccirilli JA and Harris ME. (2014). Altered (transition) states: Mechanisms and transition states of solution and enzyme catalyzed RNA 2′-O-transphosphorylation. Curr Opin Chem Biol. 21:96–102. 2014 Kellerman et al Curr Op Chem Biol
  • Porwal SK, Furia E, Harris ME, Viswanathan R, and Devireddy L. (2015). Synthetic, potentiometric and spectroscopic studies of chelation between Fe(III) and 2,5-DHBA supports salicylate-mode of siderophore binding interactions. J Inorg Biochem. 145C:1-10. 2015 Porwal et al J Inorg Biochem
  • Dissanayake T, Swails J, Harris ME, Roitberg A, York DM. (2015). Interpretation of pH-activity profiles for acid-base catalysis from molecular simulations. Biochemistry. 54(6):1307-13. 2015 Dissanayake et al Biochemistry
  • Kellerman DL, Simmons KS, Pedraza M, Piccirilli JA, York DM and Harris ME. (2015). Determination of HDV ribozyme N(-1) nucleobase and functional group modification using internal competition kinetics. Anal Biochem. 483: 12-20. 2015 Kellerman et al Anal Biochem
  • Mojica MF, Mahler GS, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. (2015). Exploring the role of residue 228 for substrate and inhibitor recognition by VIM metallo-β-lactamases. Biochemistry. 54 (20): 3183-96. 2015 Mojica et al Biochemistry
  • Koo S, Lu J, Li, N-S, Leung E, Das S, Harris ME, and Piccirilli JA. (2015). Transition state features in the Hepatitis Delta Virus (HDV) ribozyme reaction revealed by atomic perturbations . J Am Chem Soc. 137(28):8973-82. 2015 Koo et al J Am Chem Soc
  • Radak BK, Lee TS, Harris ME, York DM. (2015). Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM . RNA. (9):1566-77. 2015 Radak et al RNA
  • Chen H, Piccirilli JA, Harris ME and York DM. (2015). Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2′-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 1854(11):1795-800. 2015 Harris et al BBA_2
  • Harris ME, Piccirilli JA and York DM. (2015). Integration of kinetic isotope effects in the analysis of ribonuclease mechanism. Biochim Biophys Acta. 1854(11):1801-8. 2015 Harris et al BBA
  • Weissman BP, Li N-S, York DM, Harris ME, and Piccirilli JA. (2015). Heavy atom labeled nucleotides for measurement of kinetic isotope effects. Biochim Biophys Acta. 1854(11):1737-45.
  • Jankowsky E and Harris ME. (2015). Specificity and non-specificity in RNA-protein interactions. Nat Rev Molec Cell Biol. 16(9):533-44. 2015 Jankowsky_Harris Nat Rev Mol Cell Biol
  • Ahmad M, Huff S, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Viswanathan R, Miyagi M, Dealwis CG. (2015). Identification of non-nucleoside human ribonucleotide reductase inhibitors . J Med Chem. 58(24):9498-509. 2015 Ahmad et al J Med Chem
  • Harris ME. (2016). Theme and variation in 5′-tRNA processing endonucleases: Comparative analysis of ribonucleoprotein versus protein versions of ribonuclease P . J Molec Biol. 428(1):5-9. 2016 Harris J Molec Biol
  • Lee T-S, Radak BK, Harris ME and York DM. (2016). A two metal ion conformational switch pathway for HDV ribozyme activation. ACS Catalysis. 126, 1843-1853. 2016 Lee et al ACS Catalysis
  • Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM and Harris ME. (2016). Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+. Chem Comm. 52(24):4462-5. 2016 Zhang et al Chem Comm
  • Misko TA, Wijerathna SR, Radivoyevitch TJ, Berdis AJ, Ahmad MF, Harris ME and Dealwis CG. (2016). Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett. 590(12):1704-12. 2016 Misko et al FEBS Letters
  • Mullins M, Malligarjunan R, Hernandez-Sanchez W, de la Fuente M, Biendarra S, Harris ME and Taylor, D. (2016). POT1-TPP1 binding to telomere DNA discriminates between G-quadruplex topologies . J Molec Biol. 428(13):2695-708. 2016 Mullins et al J Molec Biol
  • Niland CN, Zhao J, Lin H-C, Jankowsky E and Harris ME. (2016). The global specificity landscape for ribonuclease P processing of pre-tRNA 5′ leader sequences . ACS Chem Biol. 11(8):2285-92. 2016 Niland et al ACS Chem Biol
  • Niland CN, Jankowsky E and Harris ME. (2016). Optimization of High Throughput Sequencing Kinetics (HTS-Kin) for the simultaneous determination of enzymatic rate constants for thousands of RNA substrates. (2016). Anal. Biochem. 510:1-10. 2016 Niland et al Anal Biochem
  • Vijayaraghavan J, Kramp K, Harris ME and van den Akker. (2016). Inhibition of activated soluble guanylyl cyclase by small molecules targeted to the catalytic domain . FEBS Lett. 590(20):3669-3680. 2016 Vijayaraghavan et al FEBS Letters
  • Knappenberger AJ, Ahmad FM, Dealwis CG and Harris ME. (2016). Nucleotide effector analogs allosterically regulate human ribonucleotide reductase and identify chemical determinants of substrate specificity. Biochemistry. 55(41):5884–5896. 2016 Knappenberger et al Biochemistry
  • Lin H-C, Zhao J, Niland CN, Tran B, Jankowsky E and Harris ME. (2016). Comprehensive analysis of the C5 protein specificity landscape reveals RNA structure and sequence preferences that direct ribonuclease P substrate specificity. Cell Chem Biol. 23(10):1271-1281. 2016 Lin et al Cell Chem Biol
  • Jain N, Lin H-C, Harris ME and Tolbert B. (2017). Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution. Proc Natl Acad Sci. 114(9):2206-2211. 2017 Jain et al PNAS
  • Jankowsky E and Harris ME. (2017). Mapping specificity landscapes of RNA-protein interactions by high throughput sequencing. Methods. S1046-2023(17)30099-3. 2017 Jankowsky_Harris Methods
  • Niland CN, Anderson DR, Jankowsky E, and Harris ME. (2017). The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5′ leader sequences . RNA. 23(10):1502-1511.
  • Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, and Dealwis CG. (2017). Potent competitive inhibition of human ribonucleotide reductase by a non-nucleoside small molecule. Proc Natl Acad Sci. 114(31):8241-8246. 2018 Ahmad et al PNAS
  • Harris ME, Piccirilli JA and Anderson VE. (2017). Kinetic isotope effect analysis of RNA 2′-O-transphosphorylation. Methods Enzymol. Vol 596, 433-457. 2017 Harris et al Meth Enzymol
  • Harris ME and Anderson VE. (2017). Preface to Measurement and Analysis of Kinetic Isotope Effects. Methods Enzymol. Vol 596, xv-xviii. 2017 Harris et al Meth Enzymol_pre
  • Knappenberger AJ, Grandhi S, Sheth R, Ahmad MD, Viswanathan R, and Harris ME (2017). Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem. 292(40):16463-16476. 2017 Knappenberger et al J Biol Chem
  • Huff S, Ahmad MF, Yang M, Agrawal P, Pink J, Harris ME, Dealwis C, Viswanathan R (2018). Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J. Med Chem. 61(3):666-680. 2018 Huff et al J Med Chem
  • Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA. (2018). Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State. Biochemistry. 26;57(25):3465-3472.

  • Zhao J, Harris ME. (2019). Distributive enzyme binding controlled by local RNA context results in 3′ to 5′ directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P. Nucleic Acids Res. 47(3):1451-1467.

  • Bevilacqua PC, Harris ME, Piccirilli JA, Gaines C, Ganguly A, Kostenbader K, Ekesan Ş, York DM. (2019). An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes. ACS Chem Biol. 14(6):1068-1076.
  • Misko TA, Liu YT, Harris ME, Oleinick NL, Pink J, Lee HY, Dealwis CG. (2019). Structure-guided design of anti-cancer ribonucleotide reductase inhibitors. J Enzyme Inhib Med Chem. 34(1):438-450.